This book explores the multifaceted challenges and opportunities related to compliance with the Sustainable Development Goals (SDGs), beginning with an analysis of municipal institutional capacities and their intrinsic link to sustainable development, followed by insights into governance within Mexico’s health sector during the COVID-19 pandemic and a critical review of green finance in major Latin American economies. It then presents innovative proposals for advancing the SDGs, including transdisciplinary approaches to decent work, an integrated causal map for promoting SMEs in Mexico’s creative industries, and the sustainability of communal enterprises within the new institutional economy. Further topics include systemic perspectives on social entrepreneurship in tourism, the empowerment of women through pantry shopping, and the intersection of social entrepreneurship with sustainable water management in tourism. The final section reflects on the consequences of failing to meet the SDGs, emphasizing the role of planetary citizenship and humanistic education in bridging existing gaps, and proposing degrowth as a radical alternative to current development paradigms.